Thrombin

CAS No. 9002-04-4

Thrombin ( Thrombin )

Catalog No. M27107 CAS No. 9002-04-4

Thrombin is a trypsin-like allosteric serine protease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Thrombin
  • Note
    Research use only, not for human use.
  • Brief Description
    Thrombin is a trypsin-like allosteric serine protease.
  • Description
    Thrombin is a trypsin-like allosteric serine protease.(In Vitro):Low concentrations of thrombin and thrombin preconditioning yield the potential of rescuing cells and to induce survival of neurons and astrocytes exposed to various ischemic insults.(In Vivo):Elevated thrombin activity was found in the brain slices from mice that were treated (in vitro and in vivo) with paraoxon. Increased levels of PAR-1 and pERK proteins and decreased prothrombin mRNA were found in the brains of paraoxon-treated mice. Furthermore, ex vivo and in vivo electrophysiological experiments showed that exposure to paraoxon causes elevated electrical activity in CA1 and CA3 regions of the hippocampus. Moreover, a specific PAR-1 antagonist (SCH79797) reduced this activity. Altogether, these results reveal the importance of thrombin and PAR-1 in paraoxon poisoning.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Thrombin
  • Pathway
    Autophagy
  • Target
    Thrombin
  • Recptor
    neuropeptide Y (NPY) Y1 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    9002-04-4
  • Formula Weight
    37kDa
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kokare DM, et, al. Interaction between neuropeptide Y and alpha-melanocyte stimulating hormone in amygdala regulates anxiety in rats. Brain Res. 2005 May 10;1043(1-2):107-14.
molnova catalog
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