Thrombin

Research use only, not for human use.

Thrombin is a trypsin-like allosteric serine protease.

Thrombin is a trypsin-like allosteric serine protease.(In Vitro):Low concentrations of thrombin and thrombin preconditioning yield the potential of rescuing cells and to induce survival of neurons and astrocytes exposed to various ischemic insults.(In Vivo):Elevated thrombin activity was found in the brain slices from mice that were treated (in vitro and in vivo) with paraoxon. Increased levels of PAR-1 and pERK proteins and decreased prothrombin mRNA were found in the brains of paraoxon-treated mice. Furthermore, ex vivo and in vivo electrophysiological experiments showed that exposure to paraoxon causes elevated electrical activity in CA1 and CA3 regions of the hippocampus. Moreover, a specific PAR-1 antagonist (SCH79797) reduced this activity. Altogether, these results reveal the importance of thrombin and PAR-1 in paraoxon poisoning.

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Thrombin

Autophagy

Thrombin

neuropeptide Y (NPY) Y1 receptor

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9002-04-4

37kDa

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years